Nitrite is a common food additives. Itself as well as the nitrosamine generated by heating reaction of nitrite with amino acid are both mutagenic agents of DNA.()
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In the process of depurination sites repairing and nucleotide excision repairing, the glycosidase is needed to catalyze the ligation of correct bases to pentose.()
The oxidative damage of bases in DNA can occur spontaneously.()
The hydrolytic deamination of 5-methylcytosine is the hotpot of mutations in the genome.()
The cytosine in nucleic acid can be easily hydrolyzed to become its deaminized form, so there are many CTPs in the genome.()