题目内容

The cytosine in nucleic acid can be easily hydrolyzed to become its deaminized form, so there are many CTPs in the genome.()

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Which kind of the mutations is most irreversible:()

A. Deletion or insertion of nucleotide
B. Hydrolytic deamination
C. Octaoxa-guanine
D. Pyrimidine dimer
E. Depurination sites

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Insertion or deletion of base-pairs will cause frameshift mutation. Which of the following compounds can most likely to result in this kind of mutation:()

Acridine derivatives
B. 5-bromouracil
C. Azathioprine
D. Ethyl ethanesulfonic acid

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During cultivation of E.coli, the spontaneous point mutations are largely caused by:()

A. The tautomeric shift of hydrogen atom
B. The broken of DNA sugar-phosphate backbone
C. The insertion of one base-pair
D. The cross-linking of inter-strands

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The most common form of ultraviolet irradiation-induced DNA damage is the generation of thymine dimer. Which of the following statement is correct about changes of DNA structure in this process:()

A. It is the covalent linkage between thymines of the two complementary polynucleotide chain
B. It can be repaired by the relevant enzyme system including nucleotide excision repair system
C. It is catalyzed by thymine dimeric enzyme
D. It will not affect DNA replication process

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