The oxidative damage of bases in DNA can occur spontaneously.()
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The hydrolytic deamination of 5-methylcytosine is the hotpot of mutations in the genome.()
The cytosine in nucleic acid can be easily hydrolyzed to become its deaminized form, so there are many CTPs in the genome.()
Which kind of the mutations is most irreversible:()
A. Deletion or insertion of nucleotide
B. Hydrolytic deamination
C. Octaoxa-guanine
D. Pyrimidine dimer
E. Depurination sites
Insertion or deletion of base-pairs will cause frameshift mutation. Which of the following compounds can most likely to result in this kind of mutation:()
Acridine derivatives
B. 5-bromouracil
C. Azathioprine
D. Ethyl ethanesulfonic acid