In the process of depurination sites repairing and nucleotide excision repairing, the glycosidase is needed to catalyze the ligation of correct bases to pentose.()
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The oxidative damage of bases in DNA can occur spontaneously.()
The hydrolytic deamination of 5-methylcytosine is the hotpot of mutations in the genome.()
The cytosine in nucleic acid can be easily hydrolyzed to become its deaminized form, so there are many CTPs in the genome.()
Which kind of the mutations is most irreversible:()
A. Deletion or insertion of nucleotide
B. Hydrolytic deamination
C. Octaoxa-guanine
D. Pyrimidine dimer
E. Depurination sites