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Paired Sets of coated Proteins Mediate Fusion of Vesicles with Target Membrane

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A Phospholipid Anchor Tethers Some Cell-Surface Proteins both to the exoplasmic and cytosolic face of cellular membrane.

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Caspase cascade is dominant in apoptotic signaling while phosphorylation cascade plays important roles in necroptotic signal transduction.

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Which caspase is the initiator caspase in intrinsic apoptosis?

A. Caspase-9
B. Caspase-8
Caspase-1
D. Caspase-4

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START is a point at late G1 when cells are irreversibly committed to completing DNA replication and mitosis. Cancer cells typically lose START control. Which of the following statement is wrong ?

A. Overexpression of cyclin D bypasses the requirement for growth factors, which normally induce synthesis of cyclin D
B. Loss of Rb (Retinoblastoma) protein function will cause E2F to be constitutively inactive and failure to enter S phase.
C. p16 (INK4A) is an inhibitor of G1/S-CDK complexes. If p16 function is lost, this promotes activation of G1/S-CDK complexes and entry into S phase.
D. E2F proteins are transcription factors that stimulate expression of genes whose products are required for entry and progression through S phase.

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