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A Phospholipid Anchor Tethers Some Cell-Surface Proteins both to the exoplasmic and cytosolic face of cellular membrane.

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Caspase cascade is dominant in apoptotic signaling while phosphorylation cascade plays important roles in necroptotic signal transduction.

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Which caspase is the initiator caspase in intrinsic apoptosis?

A. Caspase-9
B. Caspase-8
Caspase-1
D. Caspase-4

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START is a point at late G1 when cells are irreversibly committed to completing DNA replication and mitosis. Cancer cells typically lose START control. Which of the following statement is wrong ?

A. Overexpression of cyclin D bypasses the requirement for growth factors, which normally induce synthesis of cyclin D
B. Loss of Rb (Retinoblastoma) protein function will cause E2F to be constitutively inactive and failure to enter S phase.
C. p16 (INK4A) is an inhibitor of G1/S-CDK complexes. If p16 function is lost, this promotes activation of G1/S-CDK complexes and entry into S phase.
D. E2F proteins are transcription factors that stimulate expression of genes whose products are required for entry and progression through S phase.

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Proteins in signaling pathways use a variety of binding domains to assemble into signaling complexes. If matching the following domains with their binding targets，Which one is correct? a. PH domain 1. phosphorylated tyrosines b. PTB domain 2. proline-rich sequences c. SH2 domain 3. phosphorylated inositol phospholipids d. SH3 dom

A. a and 1
B. b and 2
C. c and 3
D. d and 3

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