题目内容

Which following description about Statins is correct? ( )

A. Statins inhibit Vitamin K reductase
B. Statins could prevent the liver from making lipids especially cholesterol
C. Statins inhibit Acetoacetyl –CoA transferase
D. Statins activate Mevalonate kinase
E. Statin increase the activity of HMG-CoA synthase

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Which of the following routes of administration has the highest bioavailability?()

A. Intramuscular
B. Intravascular
C. Oral
D. Subcutaneous
E. Sublingual

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A patient was given a 400 mg dose of a drug IV, and 200 mg was eliminated during the first 2 hours. If the drug follows first-order elimination kinetics, how much of the drug will remain 6 hours after its administration? ( )

A. 50
B. 125 mg
C. 150 mg
D. 175 mg
E. 350 mg

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Drugs that are highly bound to albumin:( )

A. Effectively cross the BBB
B. Are easily filtered at the glomerulus
C. Have a large Vd
D. Often contain quaternary nitrogens
E. Can undergo competition with other drugs for albumin binding sites

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If a drug is known to be distributed into total body water, what dose () is needed to obtain an initial plasma level of 5 mg/L in a patient weighing 100 kg?( )

A. 200
B. 300
C. 600
D. 800
E. 1000

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Which following description about Statins is correct? ( )

A. Statins inhibit Vitamin K reductase B. Statins could prevent the liver from making lipids especially cholesterol C. Statins inhibit Acetoacetyl –CoA transferase D. Statins activate Mevalonate kinase E. Statin increase the activity of HMG-CoA synthase

Which of the following routes of administration has the highest bioavailability?()

A patient was given a 400 mg dose of a drug IV, and 200 mg was eliminated during the first 2 hours. If the drug follows first-order elimination kinetics, how much of the drug will remain 6 hours after its administration? ( )

Drugs that are highly bound to albumin:( )

If a drug is known to be distributed into total body water, what dose () is needed to obtain an initial plasma level of 5 mg/L in a patient weighing 100 kg?( )

A. Statins inhibit Vitamin K reductase
B. Statins could prevent the liver from making lipids especially cholesterol
C. Statins inhibit Acetoacetyl –CoA transferase
D. Statins activate Mevalonate kinase
E. Statin increase the activity of HMG-CoA synthase