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A patient was given a 400 mg dose of a drug IV, and 200 mg was eliminated during the first 2 hours. If the drug follows first-order elimination kinetics, how much of the drug will remain 6 hours after its administration? ( )

A. 50
B. 125 mg
C. 150 mg
D. 175 mg
E. 350 mg

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Drugs that are highly bound to albumin:( )

A. Effectively cross the BBB
B. Are easily filtered at the glomerulus
C. Have a large Vd
D. Often contain quaternary nitrogens
E. Can undergo competition with other drugs for albumin binding sites

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If a drug is known to be distributed into total body water, what dose () is needed to obtain an initial plasma level of 5 mg/L in a patient weighing 100 kg?( )

A. 200
B. 300
C. 600
D. 800
E. 1000

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Which of the following is a phase II drug metabolism reaction associated with a genetic polymorphism? ( )

Acetylation
B. Glucuronidation
C. Oxidation
D. Reduction
E. Glutathione conjugation

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A 300-mg dose of a drug has therapeutic efficacy for 6 h. If the half-life of the drug is 8 h, for how long would a 1200mg dose be effective? ( )

A. 12 h
B. 16 h
C. 18 h
D. 20 h
E. 22 h

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A patient was given a 400 mg dose of a drug IV, and 200 mg was eliminated during the first 2 hours. If the drug follows first-order elimination kinetics, how much of the drug will remain 6 hours after its administration? ( )

A. 50 B. 125 mg C. 150 mg D. 175 mg E. 350 mg

Drugs that are highly bound to albumin:( )

If a drug is known to be distributed into total body water, what dose () is needed to obtain an initial plasma level of 5 mg/L in a patient weighing 100 kg?( )

Which of the following is a phase II drug metabolism reaction associated with a genetic polymorphism? ( )

A 300-mg dose of a drug has therapeutic efficacy for 6 h. If the half-life of the drug is 8 h, for how long would a 1200mg dose be effective? ( )

A. 50
B. 125 mg
C. 150 mg
D. 175 mg
E. 350 mg