Probenecid can increase the efficacy of penicillin, because ( )
A. probenecid can promote the absorption of penicillin
B. they have synergic bactericidal mechanisms
C. probenecid can inhibit penicillinase
D. probenecid can promote metabolism of penicillin
E. probenecid competes with penicillin for excretion in the renal tubules
The correct treatment and rational for phenobarbital sodium poisoning is that ( )
A. alkalizing the urine, the dissociation is reduced, so that the reabsorption of phenobarbital sodium in the renal tubules is reduced
B. alkalizing the urine, the dissociation is increased, so that the reabsorption of phenobarbital sodium in the renal tubules is reduced
C. acidifing the urine, the dissociation is increased, so that the reabsorption of phenobarbital sodium in the renal tubules is reduced
D. acidifing the urine, the dissociation is reduced, so that the reabsorption of phenobarbital sodium in the renal tubules is increased
E. acidifing the urine, the dissociation is increased, so that the reabsorption of phenobarbital sodium in the renal tubules is increased
In pH=5.0 solution, a weak acid drug dissociates about 50%, the pKa value is ( )
A. 4
B. 5
C. 6
D. 7
E. 8
If t1/2 of certain drug is 8 hours, according to the first order elimination kinetics, the time required to reach steady state is about ( )
A. 8 hours
B. 16 hours
C. 24 hours
D. 40 hours
E. 50 hours
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