The correct treatment and rational for phenobarbital sodium poisoning is that ( )
A. alkalizing the urine, the dissociation is reduced, so that the reabsorption of phenobarbital sodium in the renal tubules is reduced
B. alkalizing the urine, the dissociation is increased, so that the reabsorption of phenobarbital sodium in the renal tubules is reduced
C. acidifing the urine, the dissociation is increased, so that the reabsorption of phenobarbital sodium in the renal tubules is reduced
D. acidifing the urine, the dissociation is reduced, so that the reabsorption of phenobarbital sodium in the renal tubules is increased
E. acidifing the urine, the dissociation is increased, so that the reabsorption of phenobarbital sodium in the renal tubules is increased
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In pH=5.0 solution, a weak acid drug dissociates about 50%, the pKa value is ( )
A. 4
B. 5
C. 6
D. 7
E. 8
If t1/2 of certain drug is 8 hours, according to the first order elimination kinetics, the time required to reach steady state is about ( )
A. 8 hours
B. 16 hours
C. 24 hours
D. 40 hours
E. 50 hours
You need to gradually reduce the amount of propranolol after you take for a long time to treat hypertension before switching to other medications. This is to avoid ( ).
A. side reaction
B. toxic reaction
C. residual effect
D. withdrawal reaction
E. allergic reaction
One of the following receptors is a ligand-gated ion channel ( ).
A. M receptor
B. GABAB receptor
C. N receptor
D. mGluRs
E. D1 receptor