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Nucleotide excision repair system is similar with mismatch system in replication process, both of which recognize the twisty DNA double helix as damaged site. So the same protein complex can be used to find damaged sites in these two system.()

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The depurination sites of DNA strand can be repaired by directly addition of bases to pentose by specific glycosylase based on complementary base pairing.()

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The prokaryotic cell is susceptible to environment and DNA damage can be easily generated, therefore its damage-removing synthase is actively expressed as a result of transcriptional activation of RecA.()

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多选题 Which of the following damages can be repaired by nucleotide excision repair system:()

A. The broken of DNA double strands
Base insertion
C. Alkylation of bases
D. The formation of thymine dimer

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Mismatch repair is based on recognition of the mismatched base during replication. Which of the following is correct about this:()

A. UvrABC system recognizes the mismatched bases and add the correct one with the help of DNA polymerase
B. If recognition happens before methylation of DNA parental strand, the sequence of repair tends to be wild type.
C. Mismatch site is usually repaired by single-strand exchange.
D. Mismatch repair relies on the repairing function which is repressed under normal conditions by the protein LexA.

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