Probenecid can increase the efficacy of penicillin, because ( )
A. probenecid can promote the absorption of penicillin
B. they have synergic bactericidal mechanisms
C. probenecid can inhibit penicillinase
D. probenecid can promote metabolism of penicillin
E. probenecid competes with penicillin for excretion in the renal tubules