Q8 – Which action is part of the global action plan to decrease resistance to antibacterial agents?
A. 1 - Promoting smoking cessation.
B. 2 - Promoting longer stay at hospital.
C. 3 - Improving awareness on antibiotic resistance.
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Q1 – Among the following antibiotics, which one is NOT an “old” molecule?
A. 1 - Aminoglycosides.
B. 2 - Colistin.
C. 3 - Daptomycin.
Q2 – A patient is infected by a multidrug resistant isolate and could be treated using “old” molecules. Which one of the following options is correct for “old” molecules?
A. 1 - They are always available.
B. 2 - They could be use without up to date recommendations.
C. 3 - They need to be regulated by professional antimicrobial stewardships.
Q1 – Which statement related to the failure of traditional antibacterial hit finding strategies is correct?
A. 1 - Enzymatic inhibitions easily translate into whole-cell activities.
B. 2 - Phenotypic-based approaches mostly afford compounds that are not specifically toxic to bacteria.
C. 3 - Screening collections are well suited to discover antibacterial hits.
Q2 – Among the following criteria, which criteria is not mandatory at hit stage?
A. 1 - In vivo efficacy in a mouse model of infection.
B. 2 - Specific antibacterial activities.
C. 3 - An acceptable development profile with sufficient patent space to optimize.
D. 4 - Limited risk to select resistant mutants.
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