Q1 – Which statement related to the failure of traditional antibacterial hit finding strategies is correct?
A. 1 - Enzymatic inhibitions easily translate into whole-cell activities.
B. 2 - Phenotypic-based approaches mostly afford compounds that are not specifically toxic to bacteria.
C. 3 - Screening collections are well suited to discover antibacterial hits.
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Q2 – Among the following criteria, which criteria is not mandatory at hit stage?
A. 1 - In vivo efficacy in a mouse model of infection.
B. 2 - Specific antibacterial activities.
C. 3 - An acceptable development profile with sufficient patent space to optimize.
D. 4 - Limited risk to select resistant mutants.
Q1 - Which of the following options is correct? The development of anti-virulence strategies has been favored by:
A. 1 - Increasing bacterial virulence.
B. 2 - Increasing bacterial resistance to antibiotics and lower impact on host’s microbiota compared to antibiotics.
C. 3 - Increased therapeutic effect of anti-virulence strategies as compared to antibiotics.
D. 4 - Broad spectrum activity against pathogens.
Q2 – Among the following options, which one is the main objective of anti-virulence drug?
A. 1 - To inhibit the growth of the bacterial pathogen.
B. 2 - To facilitate the clearance of the bacterial pathogen.
C. 3 - To block every step of the infectious process.
D. 4 - To put more evolutionary pressure on pathogens in order to eradicate them.
Q1 - Bacteriophages are viruses that infect:
A. 1 - Plant cells.
B. 2 - Bacterial cells.
C. 3 - Archaea cells.
D. 4 - Eukaryotic cells.
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