A 56-year-old man with a history of diabetes mellitus goes to the emergency department because he has had left-sided chest pain that radiates to the arm for the past 5 hours. Serial measurements of serum creatine kinase-MB levels show an elevated level 24 hours after the onset of pain. Partial thromboplastin time and prothrombin time are normal. Coronary angiography shows occlusion of the left anterior descending artery. Which of the following mechanisms is the most likely cause of thrombosis in this patient _ _
A. Stasis of blood flow
B. Damage to endothelium
C. Decreased production of tissue plasminogen activator by intact endothelial cells
Decreased antithrombin III level
E. Mutation in factor gene Ⅴ
查看答案
An experiment is conducted in which platelet function is analyzed. A substance is obtained from the dense bodies (delta granules) of normal pooled platelet from healthy blood donors. When this substance is added to platelets obtained from patients with a bleeding disorder, no platelet aggregation occurs. Adding the substance to platelets from a normal control group induces platelet aggregation. Which of the following substances is most likely to produce this effect _ _
Adenosine diphosphate
B. Antithrombin III
C. Fibronectin
D. Thromboxane A2
E. Plasminogen
In an experiment, thrombus formation is studied in areas of vascular damage. After a thrombus forms in an area of vascular injury, the propagation of the thrombus to normal arteries is prevented. Researches identify a substance that diminishes thrombus propagation by binding to thrombin, converting it to a procoagulant that activates protein C. Which of the following substance is most likely to produce this effect_ _
A. Calcium
B. Fibrin
C. Platelet factor 4
D. Prothrombin
E. Thrombomodulin
A 44-year-old man has an acute myocardial infarction. Four days later, his ejection fraction is 25%, and cardiac output is reduced. The patient becomes increasingly dyspneic, and a chest radiograph shows bilateral pulmonary edema. These pulmonary findings are most likely caused by which of the following mechanisms _ _
A. Lymphatic obstruction
B. Decreased plasma osmotic pressure
C. Decreased central venous pressure
D. Increased hydrostatic pressure
E. Acute inflammation
Within 1 hour after a gunshot wound to the abdomen, a 19-year-old man exhibits tachycardia. His skin is cool and clammy to the touch, and blood pressure is 8030 mm Hg. Which of the following organ-specific changes is most likely to occur within 2 days after this injury _ _
Acute hepatic infarction
B. Cerebral basal ganglia hemorrhage
C. Renal passive congestion
D. Pulmonary diffuse alveolar damage
E. Gangrenous necrosis of the lower legs