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The ubiquitylation of histone is associated with the activation of the gene.()

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In eukaryotic cells, the methylation of cytosine only appears in CpG island.()

HDAC can further recruit chromatin remodeling complex by acetylation of histone.()

DNA methylation leads to the change of its conformation, thus inhibit the combination of the transcription factor and the promoter.()

CpG island is a cluster of CpG in the DNA sequence. CpG island in promoter is usually methylated when the gene is activated.()