题目内容

The damage of ultraviolet irradiation to DNA mainly is:()

A. Base substitution
Broken of phosphodiester bond
C. Deletion of base
D. Formation of covalent pyrimidine dimer

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Which of the following belongs to spontaneous damage of DNA:()

A. Single-base mismatch during DNA replication
B. Formation of thymine dimer
Cytosine deoxidation
DNA cross-linking

The gap generated by hydrolysis of mismatch site in replication can be repaired by DNA polymerase I in E. coli.()

MutL can hydrolyse the sequences containing mismatch base-pairs in nascent strands of DNA, with consumption of ATP.()

In mismatch repair system of eukaryotes, the gap between Okazaki fragments can be used for MutH binding and its hydrolysis of mismatch site.()