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Whether the cause is maternal anti-bodies, heavy metals or something else, there is no question that the brains of young children with autism have unusual features. To begin with, they tend to be too big. In studies based on magnetic resonance imaging(MRI)and basic tape-measure readings , neuroscientist Eric Courchesne at Children" s Hospital of San Diego showed that while children with autism are born with ordinary-size brains, they experience a rapid expansion by age 2—particularly in the frontal lobes. By age 4, says Courchesne, autistic children tend to have brains the size of a normal 13-year-old. More recent studies by Admiral and others have found that the amygdale, an area associated with social behavior, is also oversize, a finding Admiral believes is related to the high levels of anxiety seen in as many as 80% of people with autism. Harvard pediatric neurologist Dr. Martha Herbert reported last year that the excess white matter in autistic brains has a specific distribution; local areas tend to be over connected, while links between more distant regions of the brain are weak. The brain" s right and left hemispheres are also poorly connected. It" s as if there are too many competing local services but no long distance. This observationjibesneady with imagining studies that look at live brain activity in autistic people. Studies using functional MRI show a lack of coordination among brain regions, says Marcel Just, director of Carnegie Mellon" s Center for Cognitive Brain Imaging in Pittsburgh, Pa. Just has scanned dozens of 15-to-35-year-old autistic people with IQs in the normal range, giving them thinking tasks as he monitors their brain activity. " One thing you see," says Just, " is that activity in different areas is not going up and down at the same time. There" s a lack of synchronization, sort of like a difference between a jam session and a string quartet. In autism, each area does its own thing. " What remains unclear is whether the interconnectivity problem is the result of autism or its cause. "It" s impossible to tell the chicken from the egg at this point," Just says. Autistic people have been shown to use their brains in unusual ways; they memorize alphabet characters in apart of the brain that ordinarily processes shapes. They tend to use the visual centers in the back of the brain for tasks usually handled by the prefrontal cortex. They often look at the mouth instead of the eyes of someone who is speaking. Their focus, says psychologist Ami Klin of Yale" s Child Study Center, is " not on the social allegiances—for example, the longing gaze of a mother—but physical allegiances—a mouth that moves. " The best title for the passage is______.

A. The Brain Interconnectivity
B. The Cause of Autism
C. The Autistic Brain
D. The Symptom of Autism

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For eight months he has floated in his private ocean. This morning he awakens, opens his eyes, yawns and kicks vigorously several times. His umbilical cord drifts by his questing fingers. He plays with it briefly, brings his hands up to his mouth and sucks his thumb. Over his mother" s heartbeat and the gurgles of her digestive tract, he can hear her talking with his father. Interested, he stops sucking to listen. Until recent years, we could only speculate on what life was like for an unborn baby. Then, major advances inultrasound scanningbegan opening a window to the womb; doctors could view every movement of the baby on a television—like screen. The pictures show unborn babies yawning, sucking, grasping, stretching, blinking and making faces—in short, all the things they will do after birth. Normally an unborn baby never experiences hunger or thirst. But if a mother does not consume sufficient nutrients, the baby" s diet will not be adequate either. When an unborn baby is severely malnourished—for instance, because his mother" s heavy smoking restricts blood flow to the placenta—Dr, Jason Birnholz, an ultrasound expert, believes he has seen the baby" s chest and throat making crying motions. A radio startles him awake. He blinks and grimaces at the new sensation, but then becomes interested in the music. He turns his head to bring his ear closer to the outside world. He notices the pressure of the book his mother is resting on her belly. He kicks at it, her laugh comes to him as a dull, echoing rumble. She pats the spot he kicked and, entering into the spirit of the game, he kicks back. They play several rounds before he loses interest and falls asleep. Can a mother" s stress, anger, shock or grief harm her baby No. The normal stresses and strains of life won" t hurt him. As the expert Maurers put it, such periods are the womb equivalent of having a spell of " bad weather". Some are startled when exposed to a series of loud buzzes, but some then turn an ear to listen. Severe continuous stress may be another story. It remains unclear whether problems arise from the stress itself or from the poor nutrition, smoking, drinking or drug taking that likely accompany it. In any case the baby is affected. People generally believe that______.

A. babies have already learned to stretch and make faces before they are born
B. unborn babies are able to grasp, stretch when they stay in the womb for 8 months
C. newborn babies learn to suck and yawn soon after they are born
D. babies are unable to yawn, suck or grasp until they are born

Charles Paul and his wife, Hazel, stopped using the motor home they bought several years ago; it sits idle behind their house in Richardson, Texas. Travel is just one sacrifice they made to pay for the cost of their prescriptions, more than a dozen medications for the two of them. They found relief by switching drugstores, to one in nearby McKinney. A prescription for Paul" s diabetes had cost $ 89. 88 when he got it from a national chain but dropped down to $ 58 from McKinney" s Smith Drug. Smith, which claims to be the oldest drugstore in Texas, has been getting a lot of attention since a Dallas newspaper touted its astoundingly low prices. The overwhelming response from the public has been " a little scary," says co-owner Kaylei Mosier. She says the store simply marks each prescription up enough to cover its costs, but for many prescriptions that" s a lot lower than at other stores. The Smith Drug story has highlighted a little-known fact: prescription prices vary from city to city and block to block, and a little research can save consumers hundreds or thousands of dollars. Insurance copays can make these differences invisible, but they" re a huge deal to the 45 million uninsured Americans. Why the price swings Howard Schiff, executive director of the Maryland Pharmacists Association , explains that pharmacies generally buy their drugs from a wholesaler, who doesn" t sell to every drugstore at the same price. Once the drug is in the pharmacy, each owner chooses how much to mark it up. Because fewer than 10 percent of consumers comparison-shop for prescriptions the way they might for a quart of milk—and drug prices generally are not advertised—pharmacies don" t worry that higher prices will drive people away, says Stanford economist Alan Scorensen. There is a downside to hopping from drugstore to drugstore. If people price-shop, they" re going to lose some protection that comes from having one pharmacy track all your medications. Going to many pharmacies keeps one pharmacist from noticing potentially harmful interactions between prescriptions. Comparison-shopping is further complicated because pharmacies that have the best price on one drug don" t usually have the lowest prices across the board, so finding a good price on one drug at a pharmacy does not guarantee a cheaper total bill. Some drugstores can sell drugs at a higher price than others because______.

A. people may have more choices over the same product
B. not many people know the price differences
C. some drugstores spend more on ads than others
D. drugs were bought from different wholesalers

Charles Paul and his wife, Hazel, stopped using the motor home they bought several years ago; it sits idle behind their house in Richardson, Texas. Travel is just one sacrifice they made to pay for the cost of their prescriptions, more than a dozen medications for the two of them. They found relief by switching drugstores, to one in nearby McKinney. A prescription for Paul" s diabetes had cost $ 89. 88 when he got it from a national chain but dropped down to $ 58 from McKinney" s Smith Drug. Smith, which claims to be the oldest drugstore in Texas, has been getting a lot of attention since a Dallas newspaper touted its astoundingly low prices. The overwhelming response from the public has been " a little scary," says co-owner Kaylei Mosier. She says the store simply marks each prescription up enough to cover its costs, but for many prescriptions that" s a lot lower than at other stores. The Smith Drug story has highlighted a little-known fact: prescription prices vary from city to city and block to block, and a little research can save consumers hundreds or thousands of dollars. Insurance copays can make these differences invisible, but they" re a huge deal to the 45 million uninsured Americans. Why the price swings Howard Schiff, executive director of the Maryland Pharmacists Association , explains that pharmacies generally buy their drugs from a wholesaler, who doesn" t sell to every drugstore at the same price. Once the drug is in the pharmacy, each owner chooses how much to mark it up. Because fewer than 10 percent of consumers comparison-shop for prescriptions the way they might for a quart of milk—and drug prices generally are not advertised—pharmacies don" t worry that higher prices will drive people away, says Stanford economist Alan Scorensen. There is a downside to hopping from drugstore to drugstore. If people price-shop, they" re going to lose some protection that comes from having one pharmacy track all your medications. Going to many pharmacies keeps one pharmacist from noticing potentially harmful interactions between prescriptions. Comparison-shopping is further complicated because pharmacies that have the best price on one drug don" t usually have the lowest prices across the board, so finding a good price on one drug at a pharmacy does not guarantee a cheaper total bill. Charles and his wife haven"t traveled for long because______.

A. their motor home was not in good condition
B. they wanted to save for medicines
C. they have been too weak to do so
D. they didn" t get their doctor" s permission

Whether the cause is maternal anti-bodies, heavy metals or something else, there is no question that the brains of young children with autism have unusual features. To begin with, they tend to be too big. In studies based on magnetic resonance imaging(MRI)and basic tape-measure readings , neuroscientist Eric Courchesne at Children" s Hospital of San Diego showed that while children with autism are born with ordinary-size brains, they experience a rapid expansion by age 2—particularly in the frontal lobes. By age 4, says Courchesne, autistic children tend to have brains the size of a normal 13-year-old. More recent studies by Admiral and others have found that the amygdale, an area associated with social behavior, is also oversize, a finding Admiral believes is related to the high levels of anxiety seen in as many as 80% of people with autism. Harvard pediatric neurologist Dr. Martha Herbert reported last year that the excess white matter in autistic brains has a specific distribution; local areas tend to be over connected, while links between more distant regions of the brain are weak. The brain" s right and left hemispheres are also poorly connected. It" s as if there are too many competing local services but no long distance. This observationjibesneady with imagining studies that look at live brain activity in autistic people. Studies using functional MRI show a lack of coordination among brain regions, says Marcel Just, director of Carnegie Mellon" s Center for Cognitive Brain Imaging in Pittsburgh, Pa. Just has scanned dozens of 15-to-35-year-old autistic people with IQs in the normal range, giving them thinking tasks as he monitors their brain activity. " One thing you see," says Just, " is that activity in different areas is not going up and down at the same time. There" s a lack of synchronization, sort of like a difference between a jam session and a string quartet. In autism, each area does its own thing. " What remains unclear is whether the interconnectivity problem is the result of autism or its cause. "It" s impossible to tell the chicken from the egg at this point," Just says. Autistic people have been shown to use their brains in unusual ways; they memorize alphabet characters in apart of the brain that ordinarily processes shapes. They tend to use the visual centers in the back of the brain for tasks usually handled by the prefrontal cortex. They often look at the mouth instead of the eyes of someone who is speaking. Their focus, says psychologist Ami Klin of Yale" s Child Study Center, is " not on the social allegiances—for example, the longing gaze of a mother—but physical allegiances—a mouth that moves. " Which is one of the characteristics of the autistic brain

A. Local areas tend to be somewhat connected.
B. Links between more distant regions of the brain are weak.
C. The brain" s right and left hemispheres are perfectly connected.
D. The white matter spreads all over the brain.

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