题目内容
An experiment introduces a "knockout" gene mutation into a cell line. The frequency of shrunken cells with chromatin clumping and cytoplasmic blebbing is increased, compared with a cell line without the mutation. Overall survival of the mutant cell line is reduced. Which of the following genes is most likely to be affected by this mutation? _ _
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A 53-year-old man has had marked chest pain for the past 3 hours. Laboratory findings include elevated serum creatine kinase-MB (CK-MB). He receives thrombolytic therapy with tissue plasminogen activator. After the therapy, the CK-MB further increases. Which of the following is the most likely biochemical basis for this observed rise in CK-MB? _ _
A 60-yaer-old male comes to his physician because he has noted a mass in his neck that has increased rapidly in size over the past 2 months. On physical examination a firm, non-tender 10cm mass in the left lateral posterior neck is palpated that appears to be fused cervical lymph nodes. Hepatosplenomegaly is noted. A head CT scan reveals a mass in the Waldeyer ring near the pharynx. A biopsy of the neck mass is performed and on microscopic examination shows abnormal lymphoid cells with many mitotic figures and many apoptotic nuclei. He is treated with a cocktail of cell cycle acting chemotherapeutic agents. The cervical and oral masses shrink dramatically over the next month. Based upon his history and response to treatment, the tumor cells are most likely to have which of the following features? _ _ (A Limited capacity to metastasize
A 58-year-old woman has experienced an increasing feeling of fullness in the neck for the past 3 months, and she has noted a 3-kg weight loss during that time. On physical examination, there is a firm, fixed mass in a 3×5cm area in the right side of the neck. CT scan shows a solid mass in the region of the right lobe of the thyroid gland. A biopsy of the mass is performed, and the microscopic appearance of the specimen is shown. All areas of the tumor have similar morphology. Which of the following terms best describes this neoplasm? _ _
A 59-year-old man has recently noticed blood in his urine. Cystoscopy shows a 4-cm exophytic mass involving the right bladder mucosa near the trigone. Biopsy specimens are obtained, and the patient undergoes a radical cystectomy. Examination of the excised specimen shows that a grade IV urothelial cell carcinoma has infiltrated the bladder wall. Which of the following statements regarding these findings is most appropriate? _ _
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