题目内容
A 20-year-old man has a raised, irregular, pigmented lesion on his forearm that has increased in size and become more irregular in color over the past 4 months. Physical examination shows a 0.5×1.2 cm black to brown-colored lesion with irregular borders. An excisional biopsy specimen shows a malignant melanoma that extends into the reticular dermis. Family history indicates that the patient's paternal uncle died of metastatic melanoma that spread to the liver after excision of a primary lesion on the foot. His grandfather required enucleation of the left eye because of a "dark brown" mass in the eyeball. Which of the following genes is most likely to have undergone mutation to produce these findings. _ _
查看答案
搜索结果不匹配？点我反馈
更多问题
A 32-year-old woman has experienced dull pelvic pain for the past 2 months. Physical examination shows a right adnexal mass. An abdominal ultrasound scan shows a 7.5-cm cystic ovarian mass. The mass is surgically excised. The surface of the mass is smooth, and it is nonadherent to surrounding pelvic structures. On gross examination, the mass is cystic and filled with hair. Microscopically, there is squamous epithelium, tall columnar glandular epithelium, cartilage, and fibrous connective tissue present. Which of the following is the most likely diagnosis. _ _
A 30-year-old man has a 15-year history of increasing numbers of mu1tiple benign skin nodules. On physical examination, the firm nodules average 0.5 to l cm and appear to be subcutaneous. Further examination shows numerous oval 1 to 5-cm pigmented skin lesions. Ophthalmoscopic examination shows hamartomatous nodules on the iris. A biopsy specimen of one skin nodule shows a neoplasm that is attached to a peripheral nerve. Which of the following mechanisms of transformation is most likely related to the mutation that this patient has inherited. _ _
A study of chemical carcinogenesis shows that repeated application of croton oil containing tetra-decanoylphorbolacetate (TPA, a phorbol ester), after one application of a mutagenic agent on the skin, promotes carcinogenesis. Which of the following is the most likely mechanism for this phenomenon. _ _
A 50-year-old woman undergoes screening colonoscopy as part of a routine health maintenance workup. An isolated l-cm pedunculated polyp is found in the sigmoid colon. The excised polyp histologically shows well-differentiated glands with no invasion of the stalk. Which of the following investigational research procedures can most clearly distinguish whether the polyp represents hyperplasia of the colonic mucosa or a tubular adenoma. _ _
微信支付 
支付宝支付