Q1 – Which of the following answers applies to “old antibiotics”?
A. 1 - They were marketed before 1950.
B. 2 - They are antibiotics that are no longer available in the market.
C. 3 - They are the only antibiotics that remain active for the treatment of infections due to extensively drug resistant (XDR) isolates.
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Q2 – Among the following options, which one is not correct? Old molecules could be used for treatment of infection in:
A. 1 - Extended-Spectrum ?-Lactamase producing Enterobacteriaceae.
B. 2 - Multidrug-resistant bacteria.
C. 3 - Pan drug-Resistant bacteria.
Q3 – Which one of these assertions is correct?
A. 1 - Antibacterial agents mostly originate from Natural Products.
B. 2 - High throughput screenings readily yield novel antibacterial hits.
C. 3 - Antibacterial agents are less polar and more hydrophobic than oral drugs.
Q4 – What is a Target Product Profile?
A. 1 - The list of competitor compounds with their associated profiles.
B. 2 - The description of the molecular target to be modulated.
C. 3 - The list of clinical indications and properties a Project Team Target has to reach at Candidate stage.
Q5 – Among the following options, which one is correct? Anti-virulence drugs:
A. 1 - Are likely to have increased therapeutic effects compared to antibiotics.
B. 2 - Are likely to be active in monotherapy compared to antibiotics.
C. 3 - Are likely to be more easily administered before pathogen identification compared to antibiotics.
D. 4 - Are theoretically active in immunocompromised patients compared to antibiotics.
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