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Caspase-1 is a key mediator in extrinsic apoptosis.

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Different nuclear import receptors (importins) bind different nuclear localization signals (NLSs) and thereby different cargo proteins, there can be dozens of different importins in one human cell.

Senescent cells only exist in the old

NF-ĸB signaling is important in

A. development
B. immunity
C. inflammation
D. B and C

A loss-of-function mutation in the type I TGF receptor is found in about 25% of colon cancers. A drug that has which of the following effects might counteract this mutation?

A. constitutive activation of type II TGF receptor
B. loss of Smad3 function
C. loss of Smad 4 function
D. constitutive activation of Smad3