A loss-of-function mutation in the type I TGF receptor is found in about 25% of colon cancers. A drug that has which of the following effects might counteract this mutation?
A. constitutive activation of type II TGF receptor
B. loss of Smad3 function
C. loss of Smad 4 function
D. constitutive activation of Smad3
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Thick filaments are anchored to Z disks by
A. C protein.
B. nebulin.
C. titin.
D. myomesin.
Choose the correct order of transport of protein in a secretory pathway
A. Protein synthesized in the cytoplasm->SER lumen->RER lumen->cis golgi->median golgi->Jtrans golgi->vesicicles->fusion of vesicles with plasma membrane->exocytosis
B. Protein synthesized in the cytoplasm -> RER lumen-> cis golgi->median golgi->trans golgi->vesicicles->fusion of vesicles with plasma membrane->exocytosis
C. Protein synthesized in the cytoplasm -> vesicicles->SER-> RER lumen-> cis golgi->median golgi->trans golgi-> vesicicles ->fusion of vesicles with plasma membrane->exocytosis
D. Protein synthesized in the cytoplasm -> RER lumen-> trans golgi->median golgi->cis golgi->vesicicles->fusion of vesicles with plasma membrane->exocytosis
The resting membrane potential in animal cells depends largely on _______channel
A. Na+
B. Ca2+
C. K+
D. Cl-
Ras is a _________
A. Integral membrane protein
B. lipid-anchored membrane protein
C. Peripheral membrane protein
D. Extracellular protein
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