题目内容

The immune system is equal in complexity to the combined intricacies of the brain and nervous system. The success of the immune system in defending the body relies on a dynamic regulatory communications network consisting of millions and millions of cells. Organized into sets and subsets, these cells pass information back and forth like clouds of bees swarming around a hive. The result is a sensitive system of checks and balances that produces an immune response that is prompt, appropriate, effective and self-limiting. At the heart of the immune system is the ability to distinguish between self and non-self. When immune defenders encounter cells or organisms carrying foreign or non-self molecules, the immune troops move quickly to eliminate the invaders. Virtually every body cell carries distinctive molecules that identify it as self. The body’’s immune defenses do not normally attack tissues that carry a self marker. Rather, immune cells and other body cells coexist peaceably in a state known as self-tolerance. When a normally functioning immune system attacks a non-self molecule, the system has the ability to remember the specifics of the foreign body. Upon subsequent encounters with the same species of molecules, the immune system reacts accordingly. With the possible exception of antibodies passed during lactation ( 哺乳期 ), this so-called immune system memory is not inherited. Despite the occurrence of a virus in your family, your immune system must learn from experience with the many millions of distinctive non-self molecules in the sea of microbes in which we live. Learning necessitates producing the appropriate molecules and cells to match up with and counteract each non-self invader. Any substance capable of stimulating an immune response is called an antigen. Tissues or cells from another individual (except an identical twin, whose cells carry identical self-markers ) act as antigens; because the immune system recognizes transplanted tissues as foreign, it rejects them. The body will even reject nourishing proteins unless they are first broken down by the digestive system into their primary, non-antigenic building blocks. An antigen announces its foreignness by means of intricate and characteristic shapes called epitopes( 抗原决定基), which stick out from its surface. Most antigens, even the simplest microbes, carry several different kinds of epitopes on their surface, some may even carry several hundred. Some epitopes will be more effective than others at stimulating an immune response. Only in abnormal situations does the immune system wrongly identify self as non-self and execute a misdirected immune attack. The result can be so-called autoimmune disease. The painful side effects of these diseases are caused by a person’’s immune system actually attacking itself A tissue transplanted from father to daughter would be less acceptable than that transplanted between twins because

A. the ages of the twins’’ tissues are exactly alike.
B. the twins’’ tissues bear the same self-markers.
C. the father and daughter are different in sex.
D. the twins’’ molecules possess identical memory.

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如图所示重力式挡土墙,墙背直立、光滑、填土面水平,墙高5m,墙体砌体重度γk=22kN/m3,作用在墙上的主动土压力Ea=76kN/m。 按《建筑地基基础设计规范》(GB5007-2002),挡土墙抗滑移稳定性满足()。

A. Ks=2.26≥1.35 满足
B. Ks=1.13≤1.5 不满足
C. Ks=0.955≤1.3 不满足
D. Ks=1.13≤1.5 不满足

某砌体承重结构,底层砖墙370mm厚,采用钢筋混凝土条形基础。地质条件如下:地面下3.5m厚黏土层,物理性质指标:γ=18.6kN/m,ωL-=39.4%,ωp=23.2%,ω=26.6%,ds=2.70,Es=6.9MPa,fak=200kPa。其下为淤泥质土层,物理性质指标为:ω=52%,Es=2.3MPa,fak=76kPa。上部结构荷载效应为:正常使用极限状态下的荷载效应的标准组合:Fk=210kN/m,Mk=40kN·m承载能力极限状态下的荷载效应的基本组合:Fk=235kN/m,Mk=55kN·m试设计该基础(基础底面埋深可取2.0m,基础混凝土强度等级C20;100厚混凝土垫层C10;混凝土轴心抗拉设计强度ft=1.1N/mm2;钢筋采用HPB235,钢筋强度设计值:fy=210N/mm2)。 若基础宽度b=1.8m,在最大基底压力一侧,基底边缘最大净反力Pjmax=256kPa,在墙边缘基底净反力Pj=125kPa。计算该基础底板承受的最大弯矩最接近()。

A. 54.3kN·m
B. 86.5kN·m
C 106.5kN·m
D. 148.3kN·m

[55~57]某箱形基础底面尺寸为20m×45m,基础底面埋深d=4.5m,地下水位在地面下2.5m处。地基土为均质粉土,黏粒含量13%,粉土的重度:地下水位以上γ=18.0kN/m3,地下水位以下γsat=19.00kN/m3。由现场载荷试验确定出地基承载力特征值为:fak=175kPa。上部结构传至箱形基础顶面的轴心荷载效应Fk=130.5MN。 进行地基承载力验算时,经修正后的地基承载力特征值不得小于()。

A. 205kPa
B. 235kPa
C. 215kPa
D. 145kPa

如图所示重力式挡土墙,墙背直立、光滑、填土面水平,墙高6m。填土资料如下:①填土面作用有连续均匀分布荷载q=10kPa;②填土由两层土组成,第Ⅰ层土为黏性土,γ1=18kN/m3,ck=10kPa,=20°;第Ⅱ层土为砂土,=30°,γ=18kN/m3;③填土中有地下水,地下水位在砂土表面,砂土饱和重度γsat=20kN/m3。计算作用在挡土墙上的主动土压力。 只考虑③,填土是均匀的砂土,有地下水,无均布荷载,作用在挡土墙上的主动土压力最接近()。

A. 105kN/m
B. 134kN/m
C. 128kN/m
D. 141kN/m

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