Which of the following types of the administration route is most likely to appear first pass elimination?()
A. intramuscular injection
B. inhalation administraion
C. oral administration
D. Intravenous injection
E. subcutaneous injection
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About hife life (first-order elimination kinetics), which is the wrong?()
A. It is the time taken for the plasma concentration of drug to reduce by 50%
B. It could reflect the elimination rate
C. The dosing interval may be adjusted in accordance with hife life
D. It is related to plasma concentration
E. The drug will be eliminated completely after about 4 to 5 half life
The maximal effect of a drug is called as()
A. Potency
B. Efficacy
C. Affinity
D. Toxic effect
E. Margin of safety
Property of a partial agonist is()
A. High affinity and high intrinsic activity
B. Low affinity and low intrinsic activity
C. High affinity and low intrinsic activity
D. Low affinity and high intrinsic activity
E. High affinity and no intrinsic activity
The toxic effect is produced at the()
A. therapeutic dose
B. ineffective dose
C. ED50
D. LD50
E. over dose
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