题目内容

下列叙述中哪条与吩噻嗪类抗精神失常药的构效关系不符

A. 吩噻嗪2-位代以吸电子取代基可增强活性，取代基对活性影响的顺序为CF3＞COCH3＞Cl＞H
B. 吩噻嗪10-位N与侧链氨基之间的碳原子数以三个为宜
C. 侧链氨基可以是叔胺，N-甲基吡咯烷基,
D. 侧链上的伯醇基酯化可延长药效
E. 电子等排-CH2-CH2-取代吩噻嗪环的-S-有较好的抗抑郁作用

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