About biotransformation, which is NOT right?()
A. Biotransformation is one of the main drug elimination
B. Cytochrome P450 is charactered by high selectivity
C. Some drugs inhibit the activity of hepatic microsomal enzyme
D. The main oxidase enzyme is cytochrome P450
E. Activity of cytochrome P450 exsits larger individual differences
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If phenobarbital (a weak acid drug) is overdosed, how can we accelerate its excretion?()
A. alkalize urine,increase the degree of dissociation and increase reabsorption in kidney tubules
B. alkalize urine,decrease the degree of dissociation and increase reabsorption in kidney tubules
C. alkalize urine,increase the degree of dissociation and decrease reabsorption in kidney tubules
D. acidize urine,increase the degree of dissociation and decrease reabsorption in kidney tubules
E. acidize urine,decrease the degree of dissociation and increase reabsorption in kidney tubules
In the body, the drugs that own high affinity for the receptors will()
A. be excreted slowly
B. be excreted fast
C. be absorbed fast
D. need a few doses
E. produce stronger effect
The intrinsic activity of the drugs means()
A. the capacity of membranous penetration
B. the effect when the receptors are stimulated
C. the water solubility
D. the affinity
E. liposolubility
A patient has ingested toic amounts of aspirin, which is a weak acid. Which of the following measures can increase the excretion of aspirin in the urine?()
A. administraion of a weak acid
B. administraion of ammonium chloride
C. administraion of ascorbic acid
D. administraion of a weak base (sodium bicarbonate)
E. administraion of a plcebo
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