The exchange of DNA fragments is included in DNA recombination, which involving the break and re-formation of phosphodiester bond in DNA backbone.()
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RecA protein is a sequence-specific endonuclease that acts on single strand, as well as a helicase that can dissociate single-strand DNA from double helix, the latter of which is ATP-dependent.()
What are the common characteristics of nucleotide excision repair and homologous recombination repair:()
A. The endonuclease is needed to cut one strand of DNA molecule.
B. The dysfunction of DNA caused by pyrimidine dimer can be avoided.
C. DNA polymerase is needed to synthetize single-strand DNA, repairing gaps in DNA strands.
D. Ligase is needed to make covalent bond between new fragment and the old one.
Which of the following statement is NOT correct about the non-homology end joining repair after the break of the double strands in mammal cells?()
A. The repair needs DNA-dependent protein kinase to activate nuclease Artemis
B. The terminal of DNA needs the protection of proteins such as Ku70, Ku86 etc.
C. The repair can happen at any period of cell cycle
D. Independent of DNA homology, the repair forces the two DNA broken ends to link together
E. The repair can result in exchanges between the chromosome arms but usually will not influence the expression of the relevant genes
In prokaryotic cell,the main function of protein RecA in genetic recombination is:()
A. To promote the autosynapsis and single-strand exchange between DNA molecules
B. To disassociate the single strand from the duplex DNA molecule
C. Possessing activity of cutting the single strand DNA at specific site
D. To promote the formation of the single strand DNA
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