题目内容

It has been learned in several experimental systems that proliferation and differentiation of T lymphocytes in response to tumor cells is low because tumor cells lack the necessary costimulatory molecules for lymphocyte activation. If melanoma cells from a patient were induced to express these costimulatory molecules by transfection, production of an effective antitumor response might occur. Which of the following molecules would be the best candidate for transfection of tumor cells to achieve this end?( )

A. B7
B. CD2
CD4
D. CD28
E. LFA-1

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A radioactive tracer dye is injected subcutaneously into the forearm of an experimental subject. What is the first area of the first draining lymph node that would develop significant radioactivity?( )

A. Cortex
B. Medulla
C. Paracortex
D. Primary follicle
E. Subcapsular sinus

An 18-year-old member of a college soccer team is seen by a physician because of chest tightness and dyspnea on exertion. A 15-cm mediastinal mass is detected radiographically. Eighty percent of the white blood cells in the peripheral blood are small, abnormal lymphocytes with lobulated nuclei and scant cytoplasm. Immunophenotyping of the abnormal cells shows them to be CD4+ and CD8+. Where would such cells normally be found in the body?( )

A. Bone marrow
B. Peripheral blood
C. Thymic cortex
D. Thymic medulla
E. Splenic periarteriolar lymphoid sheaths

The blood from an 8-year-old boy was analyzed by flow cytometry. The cells were treated with fluorescent-labeled antibodies to various cell surface markers before they were evaluated by flow cytometry. Which of the following markers would identify the B lymphocytes in the sample?( )

A. CD3
B. CD4
CD8
D. CD19
E. CD56

A 2-year-old boy is evaluated for a severe combined immunodeficiency disease. His bone marrow has normal cellularity. Radioactive tracer studies demonstrate a normal number of T-cell precursors entering the thymus, but no mature T lymphocytes are found in the blood or peripheral organs. Cells populating the thymus are found to lack CD3. Which of the following capabilities would his cells lack? ( )

Ability to bind cell-bound peptides
B. Ability to express CD4/CD8 coreceptors
C. Ability to produce terminal deoxyribonucleotidyl transferase
D. Ability to proliferate in response to specific antigen
E. Ability to rearrange T-cell receptor gene segments

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